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2 edition of epidemiologic study of the role of exogenous and endogenous estrogens in rheumatoid arthritis found in the catalog.

epidemiologic study of the role of exogenous and endogenous estrogens in rheumatoid arthritis

Louise Murphy

epidemiologic study of the role of exogenous and endogenous estrogens in rheumatoid arthritis

by Louise Murphy

  • 331 Want to read
  • 15 Currently reading

Published .
Written in English


Edition Notes

StatementLouise Murphy.
The Physical Object
Pagination171 leaves.
Number of Pages171
ID Numbers
Open LibraryOL19758308M
ISBN 109780494159101

The role of hormones in the pathogenesis of psoriasis vulgaris. Several exogenous factors and endogenous hormonal changes may act as triggers for psoriasis. epidemiological study on. Expanding on our research evaluating endogenous estrogens and estrogen metabolites and cancer risk, recent methodologic advances in the measurement of androgens and androgen metabolites as well as progesterone, pregnenolone, and progesterone metabolites in serum will facilitate epidemiologic studies to evaluate the role of principal estrogens.

Estrogen indications. To treat or prevent disorders that result from an estrogen deficiency. E.g. Atrophic vaginitis, hypogonadism, oral contraception (given with a progestin), uterine bleeding, vasomotor spasms of menopause/"hot flashes," osteoporosis treatment, . The study of Janele et al, ] demonstrates that ratio of hydroxylated estrogen in relation to 2-/4-hydroxylated estrogen is important for TNF secretion. It has been found that the ratio of of OHE 2 in relation to 2-/4- hydroxylated estrogen markedly stimulated TNF secretion in presence of cortisol ( Cited by: 2.

In addition, new epidemiologic evidence has indicated that among the metabolic factors, glucose metabolism, hyperinsulinemic insulin resistance, and insulin-like growth factor bioavailability may also play a role in breast cancer. These endocrine and metabolic factors may represent future targets for breast cancer by: Given the suggested role of endogenous sex hormones in RA, it is possible that exposure to preparations containing exogenous gonadal hormones, such as oral contraceptives (OC) or estrogen replacement therapy (ERT), may also influence RA development. A number of epidemiological investigations investigated whether exogenous estrogens in.


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Epidemiologic study of the role of exogenous and endogenous estrogens in rheumatoid arthritis by Louise Murphy Download PDF EPUB FB2

Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the female sex hormone estradiol and the selective estrogen receptor modulator (SERM) raloxifene in CIA in DBA/ by: 8.

Endogenous and exogenous estrogen, and raloxifene treatment lowered the serum levels of IL Increased serum IL-6 in arthritis is a marker of the general inflammatory disease. The serum levels of IL-6 were significantly lower (P Cited by: 8. The Rotterdam study is the only large single-population based study to report whether endogenous estrogens predict future dementia in older non-demented women.

Higher levels of total estradiol were associated with an increased 6 year risk of dementia (age-adjusted hazard ratio per standard deviation increase ; 95% CI ); results were similar for (calculated) bioavailable by: Role of endogenous and exogenous female sex hormones in arthritis and osteoporosis development in BQ-ncf1*/* mice with collagen-induced chronic arthritis Rheumatoid arthritis (RA) is a joint destructing autoim-mune disease affecting % of the adult population [1,2].

The distribution between men and women is ,Cited by: 8. Epidemiology is the study of the distribution and determinants of disease in human populations. 21 This definition is based on two fundamental assumptions: first, that human disease does not occur at random and, second, that human disease has causal and preventive factors that can be identified through systematic investigation of different populations or subgroups of individuals within a Cited by: The epidemiology of Rheumatoid arthritis.

of exogenous or endogenous in nature which medications used to reduce rheumatoid arthritis's symptoms. This study will Author: Sherine Gabriel. Influence of female hormonal factors, in relation to autoantibodies and genetic markers, on the development of rheumatoid arthritis in Northern Sweden: a case–control by: Endogenous and Exogenous Estrogen, Cognitive Function, and Dementia in Postmenopausal Women: Evidence from Epidemiologic Studies and Clinical Trials.

Multiple hypotheses, based on laboratory experiments, exist about the role of specific estrogen metabolites and estrogen metabolism profiles in the etiology of breast cancer.Both estrogen receptor-mediated mechanisms involving increased mitosis and proliferation and estrogen receptor-independent mechanisms involving direct DNA damage have been by: Although the systemic and local effects of exogenous (i.e., pharmacologic) GCs have been studied extensively, little is known about the role of endogenous GCs in the development and perpetuation.

The estrogens from exogenous sources may display a synergic/additive effect with that of endogenous molecules and theoretical may display sensitive effects on the immune responses. Because of the predominance of females in autoimmune diseases, it should also be taken into consideration the role of estrogens of therapeutic sources, i.e., oral Cited by: Background.

Collagen-induced arthritis (CIA) is an often-used murine model for human rheumatoid arthritis (RA). Earlier studies have shown potent anti-arthritic effects with the f. Int J Cancer38, Ewertz IVI. Influence of non-contraceptive exogenous and endogenous sex hormones on breast cancer risk in Denmark.

Int J Cancer42, Hulka BS. Effect of exogenous estrogen on postmenopausal women: the epidemiologic evidence. Obstet Gynecol Sura35, Cited by: Rheumatoid arthritis (RA) is a joint destructing autoimmune disease affecting % of the adult population [1, 2].The distribution between men and women iswith a peak incidence during menopause and in the post-partum period [].Several studies, including a population-based case-control study [], have investigated whether the use of oral contraceptives could have an impact on the Cited by: 8.

A review of available experimental, clinical, and epidemiologic data suggests that in addition to estrogens, other endogenous hormones, including progesterone, androgens, gonadotropins, prolactin, insulin, and insulin‐like growth factors, may play a role in the pathogenesis of different histopathologic types of endometrial by: Only one epidemiologic cohort, the NHS, has been used to study the role of exogenous estrogens in SLE etiology.

The NHS was assembled in and includesfemale registered nurses aged 30–55 years living in 11 states who are contacted for updated exposures and other data every 2 years and in between for supplementary information when Cited by: Rheumatoid arthritis (RA) is a chronic disease with prevalence of ∽–1% of the adult population in most Western countries ().The etiology of this disease is only partly explained by genetic factors, and it has been suggested that environmental factors may play a significant role ().Changes over time in the incidence and in the age and sex distributions of RA might implicate specific Cited by: Start studying Ch Women's Health Drugs.

Learn vocabulary, terms, and more with flashcards, games, and other study tools. Search. exogenous compounds (from a source outside our bodies) describe estrogen receptors.

because most of the endogenous estrogens are inactive when taken orally. Estrogen metabolites have been implicated in rheumatoid arthritis (RA) and cancer, although the mechanism remains unestablished. Some estrogen metabolites, which are used for the assessment of cancer risk, play an important role in RA.

The pathways by which malignancies associated with RA remain by: 3. Inactivation of the Biological Effects of Exogenous and Endogenous Estrogens by Antibodies to 17 B cells in rheumatoid arthritis synovial tissues encode focused antibody repertoires that include antibodies that stimulate macrophage TNF-α by:.

Tosato, G., Steinberg, D., and Yarchoan R. () Abnormally elevated frequency of Epstein-Barr virus-infected B cells in the blood of patients with rheumatoid arthritis. J. : Constantin Bona, Chihiro Murai, Takeshi Sasaki.The aim of this review was to appraise data from recent research concerning female hormonal factors and their association with RA disease development.

The study of female hormonal factors is challenging because serum levels may differ throughout a woman's lifetime.Exogenous Hormone Use: Oral Contraceptives, Postmenopausal Hormone Therapy, and Health Outcomes in the Nurses’ Health Study.

At the time of study, Shilpa N. Bhupathiraju, Meir J. Stampfer, Walter C. Willett, and Frank B. Hu were with the Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, by: